Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
HDAC3-IN-6
Cat.No.:HY-172133
分?式:C??H??N?O?
分?量:417.46
作?靶点:HDAC;PD-1/PD-L1;Apoptosis;ReactiveOxygenSpecies
作?通路:CellCycle/DNADamage;Epigenetics;
Immunology/Inflammation;Apoptosis;Metabolic
Enzyme/Protease;NF-κB
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性HDAC3-IN-6(CompoundSC26)是?种选择性HDAC3抑制剂，IC50为53nM。HDAC3-IN-6剂量依赖性地诱
导PD-L1的表达。HDAC3-IN-6诱导更明显的凋亡(Apoptosis)和ROS的产?。HDAC3-IN-6对结直肠癌表现
出?的抗肿瘤功效[1]。
IC50TargetHDAC1HDAC3
3.98μM(IC50)53nM(IC50)
REFERENCES
[1].SunZ,etal.DiscoveryofNovelHydrazide-BasedHDAC3InhibitorsasEpigeneticImmunomodulatorsforCancerImmunotherapy.J
MedChem.2025Feb13;68(3):3048-3064.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.