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Inhibitors?ScreeningLibraries?Proteins
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SHP2-IN-35
Cat.No.:HY-170877
分?式:C??H??FeO?
分?量:592.46
作?靶点:SHP2;PI3K;Akt;Autophagy
作?通路:ProteinTyrosineKinase/RTK;PI3K/Akt/mTOR;Autophagy
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性SHP2-IN-35(Compound3f)是SHP2的抑制剂。SHP2-IN-35在癌细胞RKO、SW480和CT26中表现出抗增殖
活性，IC50分别为5.72μM、3.71μM和1.42μM。SHP2-IN-35抑制PI3K-Akt信号通路，调节细胞周期相
关基因的表达，并诱导线粒体?噬(autophagy)。SHP2-IN-35在肿瘤微环境(TME)中抑制?些细胞因?和趋化
因?的表达，从?调节肿瘤进展[1]。
REFERENCES
[1].ZhangXZ,etal.,Ferrocenyl-SubstitutedCurcuminDerivativesasPotentialSHP-2InhibitorsforAnticolorectalCancer:Design,Synthesis
andInVitroEvaluation.ACSOmega.2024Dec18;9(52):51701-51718.
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