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NQO2-IN-1
Cat.No.:HY-168926
CASNo.:2920687-14-3
分?式:C??H??N?O?
分?量:310.35
作?靶点:ReactiveOxygenSpecies;Apoptosis
作?通路:Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κ
B;Apoptosis
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性NQO2-IN-1(Compound20b)是醌氧化还原酶（NQO）的抑制剂，可抑制NQO2，IC50为95nM。NQO2-IN-
1通过诱导ROS和细胞凋亡(apoptosis)克服NSCLC细胞对肿瘤坏死因?相关凋亡诱导配体(TRAIL)的抗性
[1]。
REFERENCES
[1].QiSJ,etal.,Discoveryofpotentquinoneoxidoreductase2inhibitorstoovercomeTRAILresistanceofnon-smallcelllungcancer.EurJ
MedChem.2025Feb16;288:117382.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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