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Inhibitors?ScreeningLibraries?Proteins
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JPHM-2-167
Cat.No.:HY-170914
CASNo.:1258877-17-6
分?式:C??H??N?O?
分?量:504.58
作?靶点:HIF/HIFProlyl-Hydroxylase
作?通路:MetabolicEnzyme/Protease
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性PHM-2-167(Compound11)是?种选择性PHD(prolylhydroxylasedomainenzyme)抑制剂。JPHM-2-167
抑制PHD2和PHD3的IC50值分别为0.253μM和3.95μM。JPHM-2-167可?于慢性肾病的研究。
REFERENCES
[1].XuJ,etal.DiscoveryofNovelandPotentProlylHydroxylaseDomain-ContainingProtein(PHD)InhibitorsforTheTreatmentofAnemia.
JMedChem.2024Jan25;67(2):1393-1405.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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1/1MasterofBioactiveMolecules—您?边的抑制剂?师