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E197
Cat.No.:HY-164587
CASNo.:2378515-04-7
分?式:C??H??ClN?O?S
分?量:392.9
作?靶点:DOCK
作?通路:Immunology/Inflammation
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性E197是DOCK5的抑制剂，可通过破坏破?细胞的?突带结构，从?抑制?吸收（在?类破?细胞中
IC50=3.44μM）。E197在表达DOCK5的HEK293细胞中抑制Rac，IC50为36μM。E197可在??卵巢切
除模型中预防?质流失[1]。
REFERENCES
[1].MounierL,etal.,Novel2,7-Diazaspiro[4,4]nonaneDerivativestoInhibitMouseandHumanOsteoclastActivitiesandPreventBoneLoss
inOvariectomizedMicewithoutAffectingBoneFormation.JMedChem.2020Nov25;63(22):13680-13694.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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1/1MasterofBioactiveMolecules—您?边的抑制剂?师