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DXR-IN-4
Cat.No.:HY-170783
分?式:C??H??NO?PS
分?量:391.42
作?靶点:Parasite
作?通路:Anti-infection
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性DXR-IN-4(Compound12a)是1-脱氧-D-?酮糖5-磷酸还原异构酶(DXR)的抑制剂。DXR-IN-4在恶性疟原?
Plasmodiumfalciparum、?肠杆菌Escherichiacoli和结核分枝杆菌Mycobacteriumtuberculosis中抑制
DXR，PfDXR,EcDXR,andMtDXR的IC50分别为18、4.9和89nM。DXR-IN-4表现出抗疟活性，可抑制恶
性疟原?菌株3D7和Dd2，IC50分别为11μM和12μM[1]。
REFERENCES
[1].KnakT,etal.,ExpandingtheChemicalSpaceofReverseFosmidomycinAnalogs.ACSMedChemLett.2024Dec23;16(1):136-143.
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1/1MasterofBioactiveMolecules—您?边的抑制剂?师