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Inhibitors?ScreeningLibraries?Proteins
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CRBNligand-181
Cat.No.:HY-W898983
CASNo.:3036607-12-9
分?式:C??H??BrFNO?
分?量:300.12
作?靶点:LigandsforE3Ligase
作?通路:PROTAC
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性CRBNligand-181是CRBN型E3泛素连接酶配体，可?于制备PROTAC。
IC50TargetCereblon
体外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseand
theotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemto
selectivelydegradetargetproteins.
REFERENCES
[1].Mileti?N,etal.WorkflowforE3LigaseLigandValidationforPROTACDevelopment.ACSChemBiol.2025Feb21;20(2):507-521.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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