Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
CRBNligand-110
Cat.No.:HY-W893194
CASNo.:2924092-72-6
分?式:C??H?BrClFNO?
分?量:320.54
作?靶点:LigandsforE3Ligase
作?通路:PROTAC
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性CRBNligand-110是CRBN型E3泛素连接酶配体，可?于制备PROTAC。
IC50TargetCereblon
体外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseand
theotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemto
selectivelydegradetargetproteins.
REFERENCES
[1].Mileti?N,etal.WorkflowforE3LigaseLigandValidationforPROTACDevelopment.ACSChemBiol.2025Feb21;20(2):507-521.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE
1/1