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Inhibitors?ScreeningLibraries?Proteins
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MAT2A-IN-23
Cat.No.:HY-170906S
CASNo.:2925324-58-7
分?式:C??H??D?F?N?O
分?量:344.37
作?靶点:MethionineAdenosyltransferase(MAT)
作?通路:Epigenetics;MetabolicEnzyme/Protease
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性MAT2A-IN-23(compound39)是?种MAT2A抑制剂，其IC50为4nM。MAT2A-IN-23在HCT-116(MTAP
?/?)和HCT-116WT细胞系中抑制SAM，IC50分别为3nM和2nM。MAT2A-IN-23在HCT-116(MTAP?/?)
和HCT-116WT细胞系中抑制SDMA，IC50分别为2nM和3000nM。MAT2A-IN-23抑制HCT-116(MTAP
?/?)细胞增殖，IC50为47nM。
REFERENCES
[1].YangS,etal.DiscoveryofNovelSpirocyclicMAT2AInhibitorsDemonstratingHighInVivoEfficacyinMTAP-NullXenograftModels.J
MedChem.2025Feb13;68(3):3480-3494.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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