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Isotenulin
Cat.No.:HY-N15297
CASNo.:10092-04-3
分?式:C??H??O?
分?量:306.35
作?靶点:P-glycoprotein
作?通路:MembraneTransporter/IonChannel
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Isotenulin通过刺激P-糖蛋?ATPase，抑制P-gp的外排功能，并且克服癌细胞的多药耐药性(MDR)。
Isotenulin在多药耐药癌细胞KB-vin和敏感癌细胞HeLaS3中表现出细胞毒性。Isotenulin与Paclitaxel(HY-
B0015)、Vinblastine(HY-13780)和Doxorubicin(HY-15142)发挥协同作?[1]。
REFERENCES
[1].ChangYT,etal.,TenulinandisotenulininhibitP-glycoproteinfunctionandovercomemultidrugresistanceincancercells.
Phytomedicine.2019Feb;53:252-262.
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