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Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

EP-3945

Cat.No.:HY-173003

CASNo.:3057176-00-5

分?式:C??H??N?O?

分?量:418.49

作?靶点:Mas-relatedG-protein-coupledReceptor(MRGPR)

作?通路:GPCR/GProtein

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性EP-3945是Mas相关G蛋?偶联受体(MRGPR)的激动剂，效?强过MRGPRD?分?激动剂β-Alanine(HY-

N0230)。MRGPR在炎症瘙痒和疼痛感觉中起重要作?。同时，MRGPR会结合Gq(MRGPRX2、MRGPRX4、

MRGPRX1与Gq耦合；MRGPRX2、MRGPRD与Gi耦合)，测得EP-3945对Gq的EC50为211.6nM。

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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