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Inhibitors?ScreeningLibraries?Proteins
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Urease-IN-20
Cat.No.:HY-170937
CASNo.:2998940-98-8
分?式:C??H?FNO?S
分?量:320.18
作?靶点:Bacterial;Apoptosis;ReactiveOxygenSpecies
作?通路:Anti-infection;Apoptosis;Immunology/Inflammation;Metabolic
Enzyme/Protease;NF-κB
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Urease-IN-20(compoundXBP2)是?种Helicobacterpylori(H.pylori)抑制剂。Urease-IN-20抑制H.pylori
的IC50为0.14μM。Urease-IN-20能够减少感染幽门螺杆菌的GES-1细胞凋亡(Apoptosis)，并降低ROS和
γH2AX的?平。Urease-IN-20表现出显著的胃黏膜保护作?，可?于幽门螺杆菌研究。
REFERENCES
[1].CaoW,etal.SynthesisandevaluationofnovelebselenderivativesasureaseinhibitorsforcombatingHelicobacterpyloriinfections.Eur
JMedChem.2025Apr5;287:117359.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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