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Inhibitors?ScreeningLibraries?Proteins
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SMD-1087
Cat.No.:HY-170828
CASNo.:3033586-04-5
分?式:C??H??ClN?O?S
分?量:986.7
作?靶点:PROTACs;SWI/SNFComplex
作?通路:PROTAC
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性SMD-1087是?种选择性靶向SMARCA2的PROTAC(DC50=8nM，Dmax=89%)，对SMARCA4的DC501
μM。SMD-1087由E3连接酶配体(S,R,S)-AHPC-Me(bluepart)(HY-112078)，靶蛋?配体SMI-1074(red
part)(HY-170817)，和PROTAClinker(1r,4r)-tert-Butyl4-(bromomethyl)cyclohexanecarboxylate(black
part)(HY-W890392)组成。其中，它的靶蛋?配体+Linker部分对应SMARCA2Ligand-LinkerConjugate-1
(HY-170829)。
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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