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NLRP3-IN-72
Cat.No.:HY-170904
CASNo.:3043952-13-9
分?式:C??H??FN?O
分?量:353.39
作?靶点:Pyroptosis;NOD-likeReceptor(NLR);InterleukinRelated;
Hemeoxygenase(HO)
作?通路:Apoptosis;Immunology/Inflammation;Metabolic
Enzyme/Protease
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性NLRP3-IN-72(Compound2)是?种苯并咪唑衍?物。NLRP3-IN-72具有抗炎抗氧化活性，对NLRP3IL-1β的
IC50为0.3μM，对细胞焦亡(pyroptosis)保护的PD50为0.4μM，以及诱导HO-1的EC50为0.6μM。
IC50TargetIL-1βHO-1
0.3μM(IC50)0.6μM(EC50)
REFERENCES
[1].RyanClark,etal.Benzimidazolederivatives.WO2024130173A1.2024-06-20.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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