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Inhibitors?ScreeningLibraries?Proteins
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NLRP3-IN-69
Cat.No.:HY-170836
CASNo.:3027608-60-9
分?式:C??H??O?
分?量:436.45
作?靶点:NOD-likeReceptor(NLR);NF-κB;NOSynthase;COX;
InterleukinRelated
作?通路:Immunology/Inflammation;NF-κB
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性NLRP3-IN-69(Compound23)抑制NF-κBp65的激活和NLRP3炎症?体的形成。NLRP3-IN-69抑制LPS
(HY-D1056)诱导的IL-1β、iNOS和COX-2的过度表达，抑制NO的?成（IC50=5.66μM），从?表现出抗
炎活性[1]。
REFERENCES
[1].YuJ,etal.,NovelCinnamicAcidDerivativesContainingNaproxenasNLRP3Inhibitors:SynthesisandEvaluationofTheirBiological
Activity.ChemBiodivers.2024Dec29:e202402700.
McePdfHeight
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