Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
MAT2A-IN-22
Cat.No.:HY-170905S
CASNo.:2925330-18-1
分?式:C??H??D?F?N?O
分?量:348.34
作?靶点:MethionineAdenosyltransferase(MAT)
作?通路:Epigenetics;MetabolicEnzyme/Protease
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性MAT2A-IN-22(Compound29-1)是?种可透过?脑屏障的和?服有效的MAT2A抑制剂，IC50为4nM。
MAT2A-IN-22对MTAP缺失的癌细胞系有选择性和抑制活性。MAT2A-IN-22具有抗肿瘤的作?。
REFERENCES
[1].YangS,etal.DiscoveryofNovelSpirocyclicMAT2AInhibitorsDemonstratingHighInVivoEfficacyinMTAP-NullXenograftModels.J
MedChem.2025Feb13;68(3):3480-3494.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE
1/1MasterofBioactiveMolecules—您?边的抑制剂?师