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Inhibitors?ScreeningLibraries?Proteins
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Scr-IN-1
Cat.No.:HY-170958
分?式:C??H??ClF?N?O?
分?量:496.87
作?靶点:Src;Apoptosis
作?通路:ProteinTyrosineKinase/RTK;Apoptosis
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Scr-IN-1(Compound4e)是?种酪氨酸激酶(Tyrosinekinase)抑制剂。它对HCT-116细胞和MIA-PaCa-2细胞
的抑制活性IC50值分别为0.16μM和1.16μM。Scr-IN-1在HCT-116细胞和MIA-PaCa-2细胞上表现出选择
性，选择性指数(SI)分别?于625和86。Scr-IN-1可诱导HCT-116结肠癌细胞发?凋亡Apoptosis，且不会引
起坏死细胞?例的变化。Scr-IN-1可能是?种新型的HCT-116细胞SRC激酶抑制剂。Scr-IN-1适?于癌症研究
。
REFERENCES
[1].Camc?-ErenM,etal.New2-indolinone-indolehybridcompoundscarryingabenzoylmoietyastyrosinekinaseinhibitors.BioorgChem.
2025Mar;156:108203.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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