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Inhibitors?ScreeningLibraries?Proteins
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FLT3/VEGFR2-IN-1
Cat.No.:HY-168493
分?式:C??H??N?O?
分?量:561.63
作?靶点:FLT3;VEGFR;HDAC;STAT;PERK
作?通路:ProteinTyrosineKinase/RTK;CellCycle/DNADamage;
Epigenetics;JAK/STATSignaling;StemCell/Wnt
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性FLT3/VEGFR2-IN-1(Compound26)是?种FLT3/VEGFR2/HDAC抑制剂，对FLT3、VEGFR2和HDAC1的
IC50分别为14.5、3.9和30.8nM。FLT3/VEGFR2-IN-1可抑制STAT3和ERK1/2的磷酸化和??病细胞的增殖
。FLT3/VEGFR2-IN-1具有抗肿瘤的活性，可?于急性髓系??病的研究。
REFERENCES
[1].TianH,etal.Design,Synthesis,andBiologicalEvaluationofNovelFms-LikeTyrosineKinase3/VEGFR2/HistoneDeacetylaseInhibitors
fortheTreatmentofAcuteMyeloidLeukemia.JMedChem.2025Feb19.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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