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Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

ATX-IN-1

Cat.No.:HY-170765

分?式:C??H??N?O?

分?量:486.48

作?靶点:Phosphodiesterase(PDE)

作?通路:MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性ATX-IN-1(compound35)是ATX的抑制剂(IC50=0.7nM)，具有抗炎活性。ATX-IN-1能够抑制TGF-β/Smad

通路，并减少胶原蛋?沉积，来减轻Bleomycin(HY-108345)的诱导的??纤维化模型。ATX-IN-1具有良好

的?服?物利?率(F=69.5%)和微粒稳定性。

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE

1/1MasterofBioactiveMolecules—您?边的抑制剂?师