TheRAD52double-ringremodelsreplication
forksrestrictingforkreversal
1,81,8122
/10.1038/s41586-025-08753-1MasayoshiHonda,MortezaaliRazzaghi,ParasGaur,EvaMalacaria,GiorgiaMarozzi,
221,61
LudovicaDiBiagi,FrancescaAntonellaAiello,EmeleetaA.Paintsil,AndrewJ.Stanfield,
Received:14November2023
11,3,73,45
BaileyJ.Deppe,LokeshGakhar,NicholasJ.Schnicker,M.AshleySpies,
Accepted:6February20252MariaSpies1??
PietroPichierri
Publishedonline:xxxxxxxx
CheckforupdatesHumanRAD52isamultifunctionalDNArepairproteininvolvedinseveralcellularevents
thatsupportgenomestability,includingprotectionofstalledDNAreplicationforks
fromexcessivedegradation1–4.Initsgatekeeperrole,RAD52bindstoandstabilizes
stalledreplicationforksduringreplicationstress,protectingthemfromreversalby
SMARCAL1motor3.ThestructuralandmolecularmechanismoftheRAD5