Abroad-spectrumlassopeptideantibiotic

targetingthebacterialribosome

1,2,3,74,5,761,2,3

/10.1038/s41586-025-08723-7ManojJangra,DmitriiY.Travin,ElenaV.Aleksandrova,ManpreetKaur,

1,2,31,2,34,51,2,31,2,3

LenaDarwish,KalinkaKoteva,DorotaKlepacki,WenliangWang,MayaTiffany,

Received:9September20241,2,31,2,34,54,5,6??

AkosiereremSokaribo,BrianK.Coombes,NoraVázquez-Laslop,YuryS.Polikanov,

Accepted:30January20254,5??GerardD.Wright1,2,3??

AlexanderS.Mankin

Publishedonline:xxxxxxxx

CheckforupdatesLassopeptides(biologicallyactivemoleculeswithadistinctstructurallyconstrained

knottedfold)arenaturalproductsthatbelongtotheclassofribosomallysynthesized

andpost-translationallymodifedpeptides1–3.Lassopeptidesactonseveralbacterial

targets4,5,butnonehavebeenreportedtoinhibittheribosome,oneofthemain

targetsofantibioticsinthebacterialcell6,7.Herewerepor